In early 2008, Prescott and twin sister Megan Prescott appeared in an episode of soap opera Doctors, playing twin sisters Amy and Charlotte Wilcox in "Dare, Double Dare, Truth". Beginning in early 2009, Prescott played Emily Fitch in series 3, 4 and 7 on Skins, with characters known as the "second generation". In March 2010, Prescott announced on her official website that she had a role in the pilot of Goth. Prescott is currently starring in the MTV drama Finding Carter, and portraying Aziza in the CBS limited event series, The Dovekeepers.
In response to a fan's question on her official website, Prescott revealed that she would prefer to not label herself regarding her sexuality, and that "labels are for cans" (following rumors regarding the homosexuality of her character in Skins), but does not believe that "people are defined by their sexuality", suggesting that "it doesn't change who you are as a person".
Following another question, Prescott revealed that while she is not 'strictly' a vegetarian, she is wary of what meat she consumes.